| Bioactivity | CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM). | ||||||||||||
| Target | Ki: 0.2 nM (AhR) | ||||||||||||
| Invitro | CAY 10465 (Compound 4i) is a selective and high-affinity AhR receptor agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM)[1]. CAY 10465 (0.01 nM-100 μM) reduces apolipoprotein A-I (apo A-I) levels in HepG2 cells, and inhibits the synthesis of the protein[2]. | ||||||||||||
| Name | CAY 10465 | ||||||||||||
| CAS | 688348-33-6 | ||||||||||||
| Formula | C15H9Cl2F3 | ||||||||||||
| Molar Mass | 317.13 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. [2]. Naem E, et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91(1-2):64-9. |
CAY 10465
CAS: 688348-33-6 F: C15H9Cl2F3 W: 317.13
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (K
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