| Bioactivity | CARM1/HDAC2-IN-1 (compound CH-1) is a dual inhibitor against CARM1 and HDAC2, with IC50 values of 3.71 nM and 4.07 nM, respectively. CARM1/HDAC2-IN-1 possesses antitumor activity[1]. |
| Invitro | CARM1/HDAC2-IN-1 可以抑制人前列腺癌细胞 DU145，RM1，LAPC4，22RV1 和 PC-3 的增殖，IC50 值分别是 0.09 μM，0.71 μM，0.68 μM，0.95 μM 和 0.43 μM[1]。 0 --> CARM1/HDAC2-IN-1 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| In Vivo | CARM1/HDAC2-IN-1（腹腔注射；0-20 mg/kg，每四天注射一次，一共注射六次）具有与剂量相关的体内抗肿瘤活性[1]。 |
| Name | CARM1/HDAC2-IN-1 |
| Formula | C35H42N8O3 |
| Molar Mass | 622.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liang S, et al. Discovery and biological evaluation of novel CARM1/HDAC2 dual-targeting inhibitors with anti-prostate cancer agents. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2241118. |