CARM1-IN-4

CAS: 2878481-07-1 F: C24H42N2O4 W: 422.60

CARM1-IN-4 (compound 11f) is a potent CARM1 inhibitor with IC50s of 9 nM and 56 nM for CARM1 and PRMT1, respectively. CA

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Bioactivity	CARM1-IN-4 (compound 11f) is a potent CARM1 inhibitor with IC50s of 9 nM and 56 nM for CARM1 and PRMT1, respectively. CARM1-IN-4 displays significant anti-proliferative effects on colorectal cancer cell lines. CARM1-IN-4 effectively inhibits the methyltransferase activity of CARM1 and prevents methylation of downstream proteins. CARM1-IN-4 induces apoptosis and shows antitumor activity[1].
Invitro	CARM1-IN-4 (compound 11f) 在 HCT116 细胞系中表现出显着的抗增殖活性 (IC50=3.13 μM)[1]。CARM1-IN-4 (0.625-5 μM；72 小时) 在 HCT116 细胞中引起剂量依赖性细胞凋亡[1]。CARM1-IN-4 (0.625-10 μM; 48小时) 有效抑制 CARM1 的甲基转移酶活性，影响细胞环境中 CARM1 底物的不对称去甲基化水平[1]。CARM1-IN-4 表现出相对较高的线粒体稳定性，在小鼠线粒体中的半衰期较长 (T1/2=217 分钟)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CARM1-IN-4 相关抗体: Apoptosis Analysis[1] Cell Line:
In Vivo	CARM1-IN-4 (compound 11f；10、25 mg/kg/天；腹腔注射；持续 12 天) 对皮下 HCT116 异种移植物的 BALB/c 裸鼠显示出明显的肿瘤抑制作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	2878481-07-1
Formula	C24H42N2O4
Molar Mass	422.60
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chenyu Liu, et al. Structure-based discovery of potent CARM1 inhibitors for colorectal cancer therapy. Eur J Med Chem. 2024 Mar 4:269:116288.