| Bioactivity | CAM741 is a selective VCAM-1 translocation inhibitor. CAM741 selectively inhibits VCAM-1 expression by inhibiting its co-translational translocation within the lumen of the endoplasmic reticulum (ER). CAM741 can be used as a molecular tool and can also be used in the research of chronic inflammation and cancer[1][2]. |
| Invitro | CAM741 (5, 10, 50, 100 nM; 24 h) 剂量依赖性地抑制瞬时转染的 HEK-293 细胞中 VCAM1 糖蛋白的表达[1]。CAM741 (10, 33, 100, 333 nM; 24 h) 剂量依赖地抑制 VCAM1 的共翻译易位[1]。CAM741在后靶向步骤抑制 VCAM1 易位，并增强 VCAM1 新生链与 Sec61 β 的相互作用[1]。 Western Blot Analysis[1] Cell Line: |
| Name | CAM741 |
| CAS | 177586-74-2 |
| Formula | C56H91N7O11 |
| Molar Mass | 1038.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Besemer J, et al. Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1. Nature. 2005 Jul 14;436(7048):290-3. [2]. Eva Pauwels, et al. Inhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to T arget the Protein T ranslocation Pathway. Int J Mol Sci 2021, 22(21), 12007. |