| Bioactivity | CAF-382 (compound B1) is an analog of SNS-032 and a CDKL5 and pan-CDK inhibitor with a weak GSK3α/β affinity (>1.8 μM) and inhibitory activity. CAF-382 inhibits CDKL5 and blocks the phosphorylation of the CDKL5 E2 domain[1]. |
| Target | IC50: ≤100 nM (CDK9, PCTK1/CDK16, PCTK2/CDK17, PCTK3/CDK18), 2.1-2.7 μM (CDKL3, CDKL4) |
| Invitro | CAF-382 (compound B1) (5 nM-5 μM) 导致 pSer222 EB2 在 5 nM 时显着降低，而总 EB2 水平没有变化[1]。 0 --> CAF-382 相关抗体: |
| Name | CAF-382 |
| Formula | C16H22N4O2S2 |
| Molar Mass | 366.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Castano A, et al. Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology. Elife. 2023 Jul 25;12:e88206. |