| Bioactivity | CA224 (Compound 1) is a selective and orally active Cdk4–cyclin D1 inhibitor with an IC50 of 6.2 µM. CA224 induces cell apoptosis and shows antitumor activity[1]. |
| Invitro | CA224 (Compound 1) (48 h) shows antiproliferation activity against human cancer cell lines[1].CA224 (18-48 h) blocks the growth of cancer cells at G0/G1 and G2/M phase of the cell cycle, and selectively kills SV40 large T-antigen transformed normal mouse embryonic liver cells (BNL SV A.8)[1][2].CA224 (0-4 µM, 30 min) inhibits tubulin polymerization and enhances the depolymerization of stabilized tubulin protein[1].CA224 (0-72 h) induces cell apoptosis in cancer cells[1].CA224 (10 μM) shows 50%, 14%, 51% and 19% inhibition of CYP3A4, CYP2D6, CYP2C9, and CYP2C19, respectively[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | CA224 |
| CAS | 883561-04-4 |
| Formula | C24H22N2O |
| Molar Mass | 354.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |