| Bioactivity | CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC50s of 8.8 and 7.0 nM, respectively. CA/MAO-B-IN-1 reveals a human oral absorption of 71.9% through in silico prediction[1]. |
| Invitro | CA/MAO-B-IN-1 (12.5-50 μM) 恢复 ROS 的水平，对 SH-SY5Y 细胞中 Aβ1-42 寡聚物诱导的神经毒性表现出神经和线粒体保护作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CA/MAO-B-IN-1 相关抗体: Cell Viability Assay[1] Cell Line: |
| Formula | C17H15NO5S |
| Molar Mass | 345.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Giovannuzzi S, et al., Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction. J Med Chem. 2024 Mar 14;67(5):4170-4193. |