| Bioactivity | C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC50 of 1.8 μM. C21 inhibits PRMT6 with an IC50 of 8.8 μM[1]. |
| Target | IC50: 1.8 μM (PRMT1); 8.8 μM (PRMT6) |
| Name | C21 |
| CAS | 1229236-78-5 |
| Sequence | Ac-Ser-Gly-[N5-(2-Chloro-1-iminoethyl)]-Orn-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys |
| Shortening | Ac-SG-[N5-(2-Chloro-1-iminoethyl)]-Orn-GKGGKGLGKGGAKRHRKV |
| Formula | C90H161ClN36O24 |
| Molar Mass | 2166.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Obiamaka Obianyo, et al. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem. 2010 Jun 14;11(9):1219-23. |
C21
CAS: 1229236-78-5 F: C90H161ClN36O24 W: 2166.92
C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC50 of 1.8 μM. C21 inhibits PRMT6 with an IC50 of
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