| Bioactivity | C-82 is a second-generation specific CBP/β-catenin antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300[1]. |
| Target | CBP/β-catenin |
| Invitro | C-82 是 PRI-724 的活性形式。C-82 抑制小鼠原代静止肝星状细胞 (HSC) 的激活，并促进培养激活的 HSC 中的细胞死亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> C-82 相关抗体: |
| In Vivo | PRI-724 是磷酸化的 C-82，在体内可快速水解为活性形式 C-82，临床前研究显示其毒性特征非常可接受[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 1422253-37-9 |
| Formula | C33H34N6O4 |
| Molar Mass | 578.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8;2(11):1751-8. |