| Bioactivity | Butyrolactone Ia is the inhibitor for the NO production with an IC50 of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056)-induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity[1]. |
| CAS | 942986-92-7 |
| Formula | C23H22O7 |
| Molar Mass | 410.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ujie Y, et al., Aspergillus terreus IFM 65899-THP-1 cells interaction triggers production of the natural product butyrolactone Ia, an immune suppressive compound. Sci Rep. 2024 Nov 16;14(1):28278. |
Butyrolactone Ia
CAS: 942986-92-7 F: C23H22O7 W: 410.42
Butyrolactone Ia is the inhibitor for the NO production with an IC50 of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056)
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