| Bioactivity | Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation[1][2]. |
| Invitro | Butibufen (0.1 μM-0.1 M; 60 min) affects cell viability and cell attachment with a high dose[2].Butibufen (1 μM; 48 h) causes a 100% cell death after 48 h exposure[2].Butibufen (2 μM-1 mM; 6 h) affects synthesis of albumin in hepatocytes[2].Butibufen (0.2-0.4 mM; 6 h) impaires gluconeogenesis from lactate and significantly inhibited ureogenesis[2]. Cell Viability Assay[2] Cell Line: |
| In Vivo | Butibufen (50 and 250 mg/kg; p.o. 8 and 3 h before sacrifice) affects acid phosphatase activity[3]. Animal Model: |
| Name | Butibufen |
| CAS | 55837-18-8 |
| Formula | C14H20O2 |
| Molar Mass | 220.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Aparicio L. Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent. Arch Int Pharmacodyn Ther. 1977 May;227(1):130-41. [2]. Castell JV, et al. A study of the relative hepatotoxicity in vitro of the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and butibufen. Xenobiotica. 1988 Jun;18(6):737-45. [3]. Alamo C, et al. Influence of butibufen on enzyme activity and lysosomal stabilization ex vivo: a comparative study with hydrocortisone and acetylsalicylic acid. Methods Find Exp Clin Pharmacol. |