| Bioactivity | Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation[1][2]. |
| Target | IC50: 7 nM (TPP II) and 10 μM (TPP I) |
| Invitro | Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) inhibits TPP II activity of cerebral membranes[2]. |
| In Vivo | Butabindide (UCL-1397; 10 mg/kg; i.v.; for 20 min) inhibits the breakdown of CCK-8 in the gastrointestinal tract and increases satiety in mice[2]. Animal Model: |
| Name | Butabindide |
| CAS | 175553-48-7 |
| Formula | C17H25N3O2 |
| Molar Mass | 303.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ganellin CR, et, al. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. J Med Chem. 2005 Nov 17;48(23):7333-42. [2]. Rose C, et, al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 1996 Apr 4;380(6573):403-9. |
Butabindide
CAS: 175553-48-7 F: C17H25N3O2 W: 303.40
Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10
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