| Bioactivity | Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic drug[1][2][3]. | ||||||||||||
| Invitro | 白消安 (120 μM; 24 小时) 以时间依赖的方式促进适度的 p53 激活，以及强烈的 Erk、p38 和 JNK 磷酸化[1]。白消安 (120 μM; 24 小时) 通过 Erk 和 p38 MAPK 通路导致 WI38 细胞过早衰老，减少 GSH 并增加 ROS 的产生，但是 NADPH 氧化酶可以抑制这种产生[1]。 Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | Busulfan | ||||||||||||
| CAS | 55-98-1 | ||||||||||||
| Formula | C6H14O6S2 | ||||||||||||
| Molar Mass | 246.30 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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