| Bioactivity | Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase[1][2]. | ||||||||||||
| Invitro | 扑虱灵 (100, 300, 1000 µM) 显著抑制 HepG2 细胞活力[1]。扑虱灵 (3, 10, 30 µM; 24 h) 促进 HepG2 细胞的能量代谢从有氧三羧酸 (TCA) 循环和氧化磷酸化向无氧糖酵解的转化[1]。扑虱灵 (3, 10, 30 µM; 24 h) 在 HepG2 细胞中抑制 Complex IV 的活性[1]。 RT-PCR[1] Cell Line: | ||||||||||||
| In Vivo | 扑虱灵 (46.3, 139, 417 mg/kg; p.o.; single) 在肝脏 (35.84%)、大脑 (23.58%)、胃 (21.94%) 和肾脏 (18.64%) 中积累[1]。扑虱灵 (46.3, 139, 417 mg/kg; p.o.; single) 使小鼠所有器官（尤其是肝脏和大脑）的 MDA 水平升高[1]。 Animal Model: | ||||||||||||
| Name | Buprofezin | ||||||||||||
| CAS | 69327-76-0 | ||||||||||||
| Formula | C16H23N3OS | ||||||||||||
| Molar Mass | 305.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Ji X, et al. Potential hepatic toxicity of buprofezin at sublethal concentrations: ROS-mediated conversion of energy metabolism. J Hazard Mater. 2016 Dec 15;320:176-186. [2]. YoshioIzawa, et al. Inhibition of chitin biosynthesis by buprofezin analogs in relation to their activity controlling Nilaparvata lugens Stål. Pestic Biochem Physiol, 1985, 24(3): 343-347. |
Buprofezin
CAS: 69327-76-0 F: C16H23N3OS W: 305.44
Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran p
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.