| Bioactivity | Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively[1][2]. Anti-cancer activity[2]. | ||||||||||||
| Invitro | Bufalin (0, 1, 2, 4 μM for 48 hours) decreases cell viability in NCI-H460 cells[2].Bufalin (2 μM) increases caspae-3, Endo G and GADD153 mRNA expression, but decreases the GRP78 mRNA expression[2]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | Bufalin | ||||||||||||
| CAS | 465-21-4 | ||||||||||||
| Formula | C24H34O4 | ||||||||||||
| Molar Mass | 386.52 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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