| Bioactivity | Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist[1][2]. |
| Invitro | Budesonide is selective for human glucocorticoid receptor (hGR; EC50=45.7 pM) over mineralocorticoid receptors (EC50=7,620 pM) in CV-1 cells[1]. Budesonide (30 min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100 ng/mL) plus ATP (5 mM) in macrophages (RAW 264.7 cells)[2]. |
| Name | Budesonide impurity C |
| CAS | 1040085-99-1 |
| Formula | C25H34O6 |
| Molar Mass | 430.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Patrizia Ferraboschi, et al. Estimation and Characterisation of Budesonide Tablets Impurities. J Pharm Biomed Anal. 2008 Jul 15;47(3):636-40. [2]. Claudia Grossmann, et al. Transactivation via the Human Glucocorticoid and Mineralocorticoid Receptor by Therapeutically Used Steroids in CV-1 Cells: A Comparison of Their Glucocorticoid and Mineralocorticoid Properties. Eur J Endocrinol. 2004 Sep;151(3): |
Budesonide impurity C
CAS: 1040085-99-1 F: C25H34O6 W: 430.53
Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active gl
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