| Bioactivity | Bucladesine (Dibutyryl cAMP; DBcAMP) is a membrane permeable selective activator that activates cyclic adenosine phosphate dependent protein kinase A (PKA). The main regulatory mechanism of Bucladesine involves the cAMP/PKA signaling pathway. When Bucladesine activates PKA, it can promote a variety of cellular processes, including neurodevelopment, growth and plasticity. In particular, the cAMP/PKA signaling pathway plays a key role in the expression of long-term enhancement (LTP) and long-term inhibition (LTD), as well as in the formation of long-term memory in the hippocampus. Bucladesine can be used to study memory formation and neuroplasticity[1]. |
| CAS | 362-74-3 |
| Formula | C18H24N5O8P |
| Molar Mass | 469.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sharifzadeh M, et al. Post-training intrahippocampal infusion of nicotine–bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats[J]. European journal of pharmacology, 2007, 562(3): 212-220. |
Bucladesine
CAS: 362-74-3 F: C18H24N5O8P W: 469.39
Bucladesine (Dibutyryl cAMP; DBcAMP) is a membrane permeable selective activator that activates cyclic adenosine phospha
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