| Bioactivity | Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2]. Bruceine D has strong anthelmintic activity against D. intermedius with an EC50 value of 0.57 mg/L[3]. |
| Invitro | Bruceine D inhibits the cell viability of H460 and A549 cells in a dose-dependent manner with IC50 values of 0.5 and 0.6 μM, respectively, at 48 h of treatment[1]. Bruceine D (0.125-1.0 μM) dose-dependently promotes chromatin condensation, Annexin V-positive cell population and caspase-dependent apoptosis in H460 and A549 cells[1]. |
| Name | Bruceine D |
| CAS | 21499-66-1 |
| Formula | C20H26O9 |
| Molar Mass | 410.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |