| Bioactivity | Brr2-IN-3 is a potent and selective Brr2 helicase allosteric Inhibitor. Brr2-IN-3 inhibits helicase activity in dose-dependent manner with an IC50 value of 1.3 μM[1]. |
| Target | IC50: 1.3 μM (Brr2) |
| Name | Brr2-IN-3 |
| CAS | 2104030-82-0 |
| Formula | C24H20N4O3S |
| Molar Mass | 444.51 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Iwatani-Yoshihara M, et al. Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J Med Chem. 2017;60(13):5759-5771. |
Brr2-IN-3
CAS: 2104030-82-0 F: C24H20N4O3S W: 444.51
Brr2-IN-3 is a potent and selective Brr2 helicase allosteric Inhibitor. Brr2-IN-3 inhibits helicase activity in dose-dep
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