| Bioactivity | Broussonin A is a potent BChE inhibitor, with an IC50 of 4.16 µM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation[1][2][3]. |
| Invitro | Broussonin A（0.1-10 µM，30 分钟）通过调节细胞周期相关蛋白的表达和视网膜母细胞瘤蛋白的磷酸化状态来抑制 VEGF-A 刺激的内皮细胞增殖[1]。Broussonin A（0-10 µM，30 分钟）消除 VEGF-A 刺激的血管生成反应，包括大鼠主动脉环的内皮细胞迁移、侵袭、管形成和微血管形成[1]。 |
| Name | Broussonin A |
| CAS | 73731-87-0 |
| Formula | C16H18O3 |
| Molar Mass | 258.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim JH, et al. Broussonin A- and B-mediated inhibition of angiogenesis by blockade of VEGFR-2 signalling pathways and integrin β1 expression. J Cell Mol Med. 2022 Feb;26(4):1194-1205. [2]. Lee JP, et al. Potent inhibition of acetylcholinesterase by sargachromanol I from Sargassum siliquastrum and by selected natural compounds. Bioorg Chem. 2019 Aug;89:103043. [3]. Chang C F, et al. Bioactive compounds from the bark of Broussonetia papyrifera after solid fermentation with a white rot fungus Perenniporia tephropora[J]. Journal of Wood Chemistry and Technology, 2020:1-14. |