| Bioactivity | Box5 TFA is a potent Wnt5a antagonist. Box5 TFA inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca2+ release. Box5 TFA inhibits cell migration. Box5 TFA has the potential for the research of melanoma[1]. |
| Target | Wnt5a |
| Invitro | Box5 TFA (100 μM) 降低 A2058 细胞中 rWnt5a (0.1 μg/mL) 刺激的 p-MARCKS 的表达[1]。 |
| Name | Box5 TFA |
| Formula | C32H51F3N6O15S2 |
| Molar Mass | 880.90 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jenei V, et al. A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19473-8. |