| Bioactivity | Bosutinib isomer is a ligand or inhibitor with high binding affinity for both Wee1 and Wee2, with Kd values of 43.7 ± 10.0 and 4.7 ± 2.3 nM, respectively[1]. |
| Invitro | Bosutinib isomer (0-10 μM) 对 HEK293T、MM1.S 和 MDA-MB-231 细胞具有高生长抑制潜力，IC50 值为 1.6 ± 0.19、3.9 ± 0.50 和 分别为 1.8 ± 0.061 μM[1]。 0 --> Bosutinib isomer 相关抗体: |
| Name | Bosutinib isomer |
| CAS | 1391063-17-4 |
| Formula | C26H29Cl2N5O3 |
| Molar Mass | 530.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhu JY, et al. Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J Med Chem. 2017 Sep 28;60(18):7863-7875. |
Bosutinib isomer
CAS: 1391063-17-4 F: C26H29Cl2N5O3 W: 530.45
Bosutinib isomer is a ligand or inhibitor with high binding affinity for both Wee1 and Wee2, with Kd values of 43.7 ± 1
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