| Bioactivity | Boc-MIF-1-Am (compound 2) is a human dopamine D2 receptor enhancer (EC50=17.82 nM) and is a bioconjugate of melanostatin (MIF-1) and amantadine. Boc-MIF-1-Am (200 μM) exhibited mild neurotoxicity in SH-SY5Y cells[1]. |
| Target | EC50: 17.82 nM (human dopamine D2 receptors, hD2R) |
| Name | Boc-MIF-1-Am |
| Formula | C28H46N4O5 |
| Molar Mass | 518.69 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Silva-Reis S C et al. Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors[J]. ACS Medicinal Chemistry Letters, 2023. |