| Bioactivity | BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC50 value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells[1][2]. |
| Target | Kv1.3, Kv4.2 |
| Name | BmP02 |
| Sequence | Val-Gly-Cys-Glu-Glu-Cys-Pro-Met-His-Cys-Lys-Gly-Lys-Asn-Ala-Lys-Pro-Thr-Cys-Asp-Asp-Gly-Val-Cys-Asn-Cys-Asn-Val (Disulfide bonds：Cys3-Cys19, Cys6-Cys24, Cys10-Cys26) |
| Shortening | VGCEECPMHCKGKNAKPTCDDGVCNCNV (Disulfide bonds：Cys3-Cys19, Cys6-Cys24, Cys10-Cys26) |
| Formula | C115H182N36O41S7 |
| Molar Mass | 2949.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu B, et al. Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel. Sci Rep. 2016 Jul 11;6:29431. [2]. Wu B, et al. BmP02 Atypically Delays Kv4.2 Inactivation: Implication for a Unique Interaction between Scorpion Toxin and Potassium Channel. Toxins (Basel). 2016 Sep 27;8(10):280. |