Bizelesin_product_DataBase

Bioactivity	Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity[1].
Invitro	Bizelesin (0-5 μM, 4 h)可以通过靶向人类癌细胞 CEM 细胞中富含 AT的 DNA 域，造成 DNA 特异性损伤，进而造成癌细胞损伤，具有潜在的癌症处理潜力[1]。 Bizelesin?(0-500 nM)在 BSC-1 细胞中，当浓度为 10 nM 时导致 50% 的 DNA 合成抑制，相比之下，浓度为 160 nM 时才抑制 50% RNA 合成，而浓度高达至 200 nM 时也没有观察到蛋白质合成的抑制[2]。
Name	Bizelesin
CAS	129655-21-6
Formula	C43H36Cl2N8O5
Molar Mass	815.70
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. J M Woynarowski, et al. AT-rich islands in genomic DNA as a novel target for AT-specific DNA-reactive antitumor drugs. J Biol Chem. 2001 Nov 2;276(44):40555-66. [2]. J M Woynarowski, et al. Effects of bizelesin (U-77,779), a bifunctional alkylating minor groove binder, on replication of genomic and simian virus 40 DNA in BSC-1 cells. Biochim Biophys Acta. 1997 Jul 17;1353(1):50-60.

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