Bisindolylmaleimide VIII

CAS: 125313-65-7 F: C24H22N4O2 W: 398.46

Bisindolylmaleimide VIII (Ro 31-7549) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM

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Bioactivity	Bisindolylmaleimide VIII (Ro 31-7549) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively[1]. Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases[1][2].
Invitro	Bisindolylmaleimide VIII (5 μM; 8, 12 hours) 显著增加 TRA-8 诱导的细胞死亡，呈时间依赖性和剂量依赖性[2]。Bisindolylmaleimide VIII (5 μM; 6 hours) 与 TRA-8 联合处理后，4 h procaspase-8 显著降低，6 h完全消失[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Bisindolylmaleimide VIII 相关抗体: Western Blot Analysis[2] Cell Line:
In Vivo	Bisindolylmaleimide VIII (100 μg;i.p;每隔一天服用三次)，结合 toTRA-8，肿瘤几乎完全消退。单独使用 Bisindolylmaleimide VIII未引起肿瘤明显消退[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	125313-65-7
Formula	C24H22N4O2
Molar Mass	398.46
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wilkinson SE, et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1;294 ( Pt 2):335-7. [2]. Ohtsuka T, et al. Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. J Biol Chem. 2002 Aug 9;277(32):29294-303.

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