| Bioactivity | Bisabosqual A, a potent asparagine synthetase (ASNS) inhibitor, with an IC50 of 10.7 μM. Bisabosqual A can covalently modify the K556 site of ASNS protein. Bisabosqual A promotes oxidative stress and apoptosis, while inhibiting autophagy, cell migration and epithelial-mesenchymal transition (EMT), impeding cancer cell development[1]. |
| Invitro | Bisabosqual A 抑制人非小细胞肺癌 A549 细胞的增殖和迁移[1]。Bisabosqual A 诱导包含 GCN2-eIF2α-ATF4、PI3K-AKT-mTORC1 和 RAF-MEK-ERK 轴的负反馈通路，但 Bisabosqual A 和雷帕霉素/torin-1 的联合作用克服了 mTOR 通路触发的潜在耐药性[1]。 0 --> Bisabosqual A 相关抗体: |
| Name | Bisabosqual A |
| CAS | 180027-46-7 |
| Formula | C23H28O5 |
| Molar Mass | 384.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pan Y, et al. Bisabosqual A: A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells. Eur J Pharmacol. 2023 Dec 5;960:176156. |
Bisabosqual A
CAS: 180027-46-7 F: C23H28O5 W: 384.47
Bisabosqual A, a potent asparagine synthetase (ASNS) inhibitor, with an IC50 of 10.7 μM. Bisabosqual A can covalently m
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