| Bioactivity | Sibiriline is a novel inhibitor of necroptosis, a regulated form of cell death associated with liver disease. Sibiriline inhibits necroptotic cell death induced by TNF in FADD-deficient Jurkat cells and by various death ligands in human or mouse cells, but does not protect cells from caspase-dependent apoptosis. Sibiriline is a specific competitive inhibitor of RIPK1 that binds to the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis and protects mice from concanavalin A-induced hepatitis, highlighting its potential to inhibit immune-dependent hepatitis[1]. |
| CAS | 73711-18-9 |
| Formula | C20H30I2N4 |
| Molar Mass | 580.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |