| Bioactivity | Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates. | ||||||||||||
| Invitro | Biotin-VAD-FMK is a synthetic peptide designed as a methyl ester to facilitate cell permeability. | ||||||||||||
| In Vivo | To examine whether caspase-2 is activated in the absence of proteolytic cleavage, an in vivo affinity labeling approach is used, using the biotinylated caspase inhibitor biotin-VAD-fmk that detects only active caspases[2]. | ||||||||||||
| Name | Biotin-VAD-FMK | ||||||||||||
| CAS | 1135688-15-1 | ||||||||||||
| Formula | C30H49FN6O8S | ||||||||||||
| Molar Mass | 672.81 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Li J, et al. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes. J Biol Chem. 1999 Jun 11;274(24):17325-33. [2]. Samraj AK, et al. Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membranedepolarization. Mol Biol Cell. 2007 Jan;18(1):84-93. |
Biotin-VAD-FMK
CAS: 1135688-15-1 F: C30H49FN6O8S W: 672.81
Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in c
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