| Bioactivity | Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer[1]. |
| Invitro | Bintrafusp alfa 可以赋予长期保护性免疫，降低调节性 T 细胞功能，显着增加 CD8+ T 细胞和自然杀伤细胞浸润，并减少肿瘤内骨髓来源的抑制细胞浸润[1]。 |
| Name | Bintrafusp alfa |
| CAS | 1918149-01-5 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Strauss J, et, al. Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies. J Immunother Cancer. 2020 Dec;8(2):e001395. |