| Bioactivity | Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity[1]. | ||||||||||||
| Invitro | Bindarit (10-300 μM; 48 hours) at 100 µM and 300 µM significantly inhibits platelet derived growth factor-BB (PDGF-BB)-induced rat VSMCs proliferation by 27% and 42%, respectively[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | Bindarit | ||||||||||||
| CAS | 130641-38-2 | ||||||||||||
| Formula | C19H20N2O3 | ||||||||||||
| Molar Mass | 324.37 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|