| Bioactivity | Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation[1]. |
| Invitro | Bigelovin (0-20 μM, 24-72 h) significantly inhibits cell viability of liver cancer cells and induces apoptosis and autophagy[1].Bigelovin causes a significant increase of p62, LC3B-II, Beclin-1 and a corresponding decrease of p62 levels in a time-dependent manner[1].Bigelovin induces cell death involves the suppression of mTOR pathway regulated by ROS production[1]. Cell Viability Assay[1] Cell Line: |
| Name | Bigelovin |
| CAS | 3668-14-2 |
| Formula | C17H20O5 |
| Molar Mass | 304.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |