| Bioactivity | Biflorin has antimicrobial, antitumor, antiinflammatory and antimutagenic activities. Biflorin is found in the roots of Capraria biflora L[1][2][3]. |
| Invitro | Biflorin (72 h) 可抑制肿瘤细胞生长，IC50s 范围为 0.58 μg/mL (NCIH23 细胞) 至 14.61 μg/mL (MDA-MB-231 细胞)[1]。Biflorin (3 和 6 μg/mL，24 小时) 可诱导 B16 黑色素瘤细胞凋亡、核小体间 DNA 断裂和线粒体去极化[1]。Biflorin 通过 STAT1 失活抑制 LPS 诱导的 RAW 264.7 巨噬细胞中一氧化氮 (NO) 和前列腺素 E2 (PGE2) 的产生，IC50 s 分别为 51.7 和 37.1 μM[2]。Biflorin (5 和 10 μg/mL，3 小时) 通过减少 V79 哺乳动物细胞中的脂质过氧化和 DNA 损伤来抑制 H2O2 诱导的氧化损伤[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Biflorin 相关抗体: |
| In Vivo | biflorin (25 mg/day，腹腔注射，持续 10 天) 可抑制 B16 黑色素瘤小鼠的肿瘤生长并提高平均存活率[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 89701-85-9 |
| Formula | C16H18O9 |
| Molar Mass | 354.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Vasconcellos MC, et al. The in-vitro and in-vivo inhibitory activity of biflorin in melanoma. Melanoma Res. 2011 Apr;21(2):106-14. [2]. Lee HH, et al. Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock. J Nat Prod. 2016 Apr 22;79(4):711-20. [3]. Vasconcellos MC,et al. Evaluation of the cytotoxic and antimutagenic effects of biflorin, an antitumor 1,4 o-naphthoquinone isolated from Capraria biflora L. Arch Toxicol. 2010 Oct;84(10):799-810. |