Bicuculline methiodide_product_DataBase

Bioactivity	Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1].
Invitro	Bicuculline methiodide (30 μM) 促进 N-甲基-d-天冬氨酸 (NMDA) 刺激，促进多巴胺神经元的爆发性放电[1]。研究表明，反奖励中枢外侧缰核（LHb）的簇状放电是抑郁症发生的充分条件。LHb神经元常分为三类：沉默型（silent）, 强直放电型（tonic-firing），簇状放电型（burst-firing）[2]。
Name	Bicuculline methiodide
CAS	40709-69-1
Formula	C21H20INO6
Molar Mass	509.29
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Johnson SW, et al. Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents. Neurosci Lett. 1997 Aug 1;231(1):13-6. [2]. Yang Y, et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression[J]. Nature, 2018, 554(7692): 317-322.

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