| Bioactivity | BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress[1][2]. | ||||||||||||
| Invitro | BiP inducer X (5 μM; 0-12 hours; SK-N-SH cells) increase BiP protein[1].The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway[1].BiP inducer X (5 μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4[1]. | ||||||||||||
| Name | BiP inducer X | ||||||||||||
| CAS | 101714-41-4 | ||||||||||||
| Formula | C9H7NO3S | ||||||||||||
| Molar Mass | 209.22 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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BiP inducer X
CAS: 101714-41-4 F: C9H7NO3S W: 209.22
BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (e
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