| Bioactivity | BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrPSc) from scrapie-infected cells, with an EC50 of 0.32 μM[1][2]. |
| Invitro | BiCAPPA (10 nM-2 μM; 5 d) 降低感染痒病的小鼠下丘脑细胞的蛋白酶 K 抗性 PrPSc，EC50 值为 0.32 μM [2]。 |
| Name | BiCAPPA |
| CAS | 119662-55-4 |
| Formula | C38H40Cl2N6O2 |
| Molar Mass | 683.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Uliassi E, et, al. 10-Medicinal Chemistry of Hybrids for Neurodegenerative Diseases. Design of Hybrid Molecules for Drug Development. 2017, Pages 259-277. [2]. Bongarzone S, et, al. Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound. J Med Chem. 2010 Nov 25;53(22):8197-201. |
BiCAPPA
CAS: 119662-55-4 F: C38H40Cl2N6O2 W: 683.67
BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (Pr
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