| Bioactivity | Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively[1][2][3]. | ||||||||||||
| In Vivo | Betamethasone valerate (10 mg; 5 minutes; applied to the irritated site with a micro spatula) ointment inhibits about 50% of the ear edema without thymus atrophy[4].Betamethasone-17-valerate ointment (50 mg) inhibits homologous passive cutaneous anaphylaxis[4]. Animal Model: | ||||||||||||
| Name | Betamethasone valerate | ||||||||||||
| CAS | 2152-44-5 | ||||||||||||
| Formula | C27H37FO6 | ||||||||||||
| Molar Mass | 476.58 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Sizílio RH, et al. Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. Carbohydr Polym. 2018 Jun 15;190:339-345. [2]. Epstein EH Jr, et al. Glucocorticoid receptors of normal human epidermis. J Invest Dermatol. 1982 Feb;78(2):144-6. [3]. WILLIAMS DI, et al. BETAMETHASONE 17-VALERATE: A NEW TOPICAL CORTICOSTEROID. Lancet. 1964 May 30;1(7344):1177-9. [4]. Iizuka Y, et al. Two simple methods for the evaluation of topically active anti-inflammatory steroidal ointments. Agents Actions. 1981 May;11(3):254-9. |
Betamethasone valerate
CAS: 2152-44-5 F: C27H37FO6 W: 476.58
Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid
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