| Bioactivity | Berotralstat (BCX7353) is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE[1][2]. |
| Target | Plasma kallikrein |
| Name | Berotralstat |
| CAS | 1809010-50-1 |
| Formula | C30H26F4N6O |
| Molar Mass | 562.56 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
| Reference | [1]. Zuraw B, et al. Oral once-daily berotralstat for the prevention of hereditary angioedema attacks: A randomized, double-blind, placebo-controlled phase 3 trial [published online ahead of print, 2020 Oct 21]. J Allergy Clin Immunol. 2020;S0091-6749(20)31484 [2]. Manning ME, et al. Berotralstat (BCX7353) is a novel oral prophylactic treatment for hereditary angioedema: Review of phase II and III studies. Allergy Asthma Proc. 2021;42(4):274-282. |
Berotralstat
CAS: 1809010-50-1 F: C30H26F4N6O W: 562.56
Berotralstat (BCX7353) is a low toxicity, effective, highly specific, second-generation, synthetic and orally active pla
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This product is for research use only, not for human use. We do not sell to patients.