| Bioactivity | Benfluorex (JP-992) is a hepatic nuclear factor 4 alpha (HNF4α) activator. |
| Target | HNF4α |
| Invitro | Benfluorex consistently activates insulin promoter activity as measured by an increased number of GFP-positive cells. Benfluorex increases the number of GFP-positive cells in a dose-responsive manner and increases the level of endogenous insulin mRNA. Consistent with being HNF4α activator, Benfluorex stimulates HNF4α expression. Benfluorex alters HNF4α protease sensitivity, while the inactive control compound does not[1]. Benfluorex decreases, in a concentration-dependent manner, the synthesis of acid-soluble products and ketone bodies from oleate, whereas the production of 14CO2 into citric acid cycle is markedly increased by Benfluorex. Benfluorex inhibits in a dose-dependent manner the rates of gluconeogenesis from lactate/pyruvate (10/1 nM)[2]. |
| Name | Benfluorex |
| CAS | 23602-78-0 |
| Formula | C19H20F3NO2 |
| Molar Mass | 351.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lee SH, et al. Identification of alverine and benfluorex as HNF4α activators. ACS Chem Biol. 2013 Aug 16;8(8):1730-6. [2]. Kohl C, et al. Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression. Diabetes. 2002 Aug;51(8):2363-8. |