| Bioactivity | Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. This protein interaction mechanism specifically targets complex I of the lipid kinase VPS34 without affecting complex II. Because the integrity of VPS34 complex II depends on the Beclin 1-UVRAG interaction. Beclin1-ATG14L interaction inhibitor 1 can disrupt the formation of VPS34 complex I and inhibit autophagy, but does not affect complex II-related vesicle transport[1]. |
| Name | Beclin1-ATG14L interaction inhibitor 1 |
| CAS | 1243063-73-1 |
| Formula | C23H24N4O5S |
| Molar Mass | 468.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pavlinov I, et al. Beclin 1-ATG14L Protein-Protein Interaction Inhibitor Selectively Inhibits Autophagy through Disruption of VPS34 Complex I. J Am Chem Soc. 2020 May 6;142(18):8174-8182. |
Beclin1-ATG14L interaction inhibitor 1
CAS: 1243063-73-1 F: C23H24N4O5S W: 468.53
Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. This protein intera
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