| Bioactivity | Bcl-2-IN-10 is an active Bcl-2 inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities against cancer cells, such as human leukemia, breast cancer and lung cancer. Bcl-2-IN-10 induces cell apopotosis and arrest cell cycle of G2/M phase, and can be used in cancer-related research[1]. |
| Invitro | Steroid sulfatase-IN-2 (compound 1, 0-20 μM approximately, 72 h) inhibits different cancer cells with IC50s ranging from 1.26 μM to 17.86 μM[1].Steroid sulfatase-IN-2 (1 μM, 5 h) releases up to four molecules of nitric oxide[1].Steroid sulfatase-IN-2 (8 μM, 8-72 h) induces leukemia cell CCRF-CEM apoptosis via MAPKs pathways, arrests cell in the G2/M phase, and increases ratio of Bax/Bcl-2[1]. Apoptosis Analysis[1] Cell Line: |
| Name | Bcl-2-IN-10 |
| CAS | 2773354-28-0 |
| Formula | C22H25N11O12 |
| Molar Mass | 635.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Bcl-2-IN-10
CAS: 2773354-28-0 F: C22H25N11O12 W: 635.50
Bcl-2-IN-10 is an active Bcl-2 inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytoto
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