| Bioactivity | Bax agonist 1 (compound SMBA2) is a Bax agonist (Ki=57.2 nM). Bax agonist 1 induces Bax conformational changes by blocking S184 phosphorylation, promoting Bax insertion into the mitochondrial membrane and forming Bax oligomers, which induce cytochrome c release and apoptosis in malignant cancer cells expressing Bax. Bax agonist 1 can be used in lung cancer research[1]. |
| CAS | 18304-79-5 |
| Formula | C8H16N4 |
| Molar Mass | 168.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Meiguo Xin, et al. Small-molecule Bax agonists for cancer therapy. Nature communications 5.1 (2014): 4935. |
Bax agonist 1
CAS: 18304-79-5 F: C8H16N4 W: 168.24
Bax agonist 1 (compound SMBA2) is a Bax agonist (Ki=57.2 nM). Bax agonist 1 induces Bax conformational changes by blocki
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