Banoxantrone_product_DataBase

Bioactivity	Banoxantrone (AQ4N), as a prototype hypoxia selective cytotoxin, can be reduced to AQ4, a potent topoisomerase II inhibitor. Banoxantrone selectively kills hypoxic cells via an iNOS-dependent mechanism. Banoxantrone shows a potent cytotoxicity and hypoxia-selective effect enhanced by radiation[1][2].
Invitro	Banoxantrone (20 μM; 90 min) 选择性诱导缺氧的 T50/80 肿瘤细胞发生损伤[1]。
In Vivo	Banoxantrone (200 mg/kg; 腹腔注射; 单剂量) 在 BDF 小鼠中显著抑制T50/80肿瘤，并诱导细胞损伤[1]。
Name	Banoxantrone
CAS	136470-65-0
Formula	C22H28N4O6
Molar Mass	444.48
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hejmadi MV, et al. DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells. Br J Cancer. 1996 Feb;73(4):499-505. [2]. Mehibel M, et al. Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase. Oncol Rep. 2016 Apr;35(4):1925-32.

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