| Bioactivity | Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism. | ||||||||||||
| Target | Ki: 1 nM (hV1a), 39 nM (mV1a) | ||||||||||||
| Invitro | Balovaptan (RG7314) shows >30000-fold selectivity for hV1a over hV2 receptors, 9891-fold selectivity over hOTR (human oxytocin receptor)[1]. | ||||||||||||
| Name | Balovaptan | ||||||||||||
| CAS | 1228088-30-9 | ||||||||||||
| Formula | C22H24ClN5O | ||||||||||||
| Molar Mass | 409.91 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89. |
Balovaptan
CAS: 1228088-30-9 F: C22H24ClN5O W: 409.91
Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Ki
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