Bactenecin_product_DataBase

Bioactivity	Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei[1][2][3].
Invitro	Bactenecin is synthesized by solid-phase peptide synthesis and renatured to a fully disulfide bonded form. Bactenecin inhibits the growth of Escherichia coli and Staphylococcus aureus at the same concentration reported for the peptide purified from bovine neutrophils. Bactenecin inhibits the growth of other medically important bacteria and yeast, and it kills the fungus Trichophyton rubrum[1]. Bactenecin, a dodecapeptide, is strongly cytotoxic to rat embryonic neurons, fetal rat astrocytes and human glioblastoma cells[2].Bactenecin exhibits stronger binding to LPS and induces perturbation of the inner membrane of live cells. Interaction of Bactenecin with model membranes results in changes in membrane fluidity and permeability, leading to leakage of dye across the membrane[3].
Name	Bactenecin
CAS	116229-36-8
Sequence	Arg-Leu-Cys-Arg-Ile-Val-Val-Ile-Arg-Val-Cys-Arg (Disulfide bridge: Cys3-Cys11)
Shortening	RLCRIVVIRVCR (Disulfide bridge: Cys3-Cys11)
Formula	C63H118N24O13S2
Molar Mass	1483.89
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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