| Bioactivity | BacPROTAC-1 is a mSA BacPROTAC degrader. BacPROTAC-1 binds mSA and ClpCNTD with high affinity (KDs of 3.9 and 2.8 μM, respectively)[1]. |
| Target | KD: 2.8 μM (ClpCNTD), 3.9 μM (mSA) |
| Invitro | mSA 单独和 mSA 融合蛋白 (mSA-NrdI、mSA-TagD、mSA-NusA、mSA-Kre) 被 ClpCP 以依赖 BacPROTAC-1 的方式降解 (1-100 μM; 2 h)。这种降解是 ATP 依赖的，pArg 或生物素阻断 BacPROTAC-1 诱导的降解[1]。BacPROTAC-1 诱导活性 ClpC 寡聚物[1]。BacPROTAC-1 (1-100 μM) 可以重编程分枝杆菌 ClpC1P1P2[1]。 |
| Name | BacPROTAC-1 |
| Formula | C45H83N12O17PS |
| Molar Mass | 1127.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Morreale FE, et al. BacPROTACs mediate targeted protein degradation in bacteria. Cell. 2022 Jun 23;185(13):2338-2353.e18. |