Bioactivity | BVT173187 is a selective inhibitor of the neutrophil formyl peptide receptor FPR1, with activity that inhibits FPR1 activation. BVT173187 inhibits FPR1 agonist-induced activation in neutrophils, reduces adhesion molecule mobilization and superoxide anion production, and has inhibitory activity on FPR1 similar to that of earlier described peptide antagonists, but also has effects on C5aR and CXCR signaling. |
CAS | 1374984-75-4 |
Formula | C14H10Cl3NO2 |
Molar Mass | 330.59 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. A non-peptide receptor inhibitor with selectivity for one of the neutrophil formyl peptide receptors, FPR 1 |