| Bioactivity | BUR1 is a BMP upregulator (EC50: 98 nM) and activates BMPRII signalling. BUR1 induces BMP2 and PTGS2 expression. BUR1 reversed pulmonary arterial pressure in Monocrotaline (HY-N0750) induced rats[1]. |
| Invitro | BUR1 (0.2 μM，15 分钟至 24 小时) 可增加 PAEC 中 DNA 结合抑制剂 1 (Id1) 的表达和 Smad1/5 的磷酸化[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BUR1 相关抗体: |
| In Vivo | BUR1 (4.5 mg/天，灌胃， 3 周) 可逆转野百合碱 诱导的大鼠肺动脉压和右心室收缩压[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 23000-46-6 |
| Formula | C16H17N5 |
| Molar Mass | 279.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xing Y, et al. A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels. Eur Respir J. 2018 Apr 4;51(4):1702229. |