| Bioactivity | BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma[1][2]. | ||||||||||||
| Invitro | BTdCPU (10 μM; 4, 8 h) BTdCPU induces phosphorylation of eIF2α and promotes cell death in MM cells[1].BTdCPU (10 μM; 4, 8 h) shows cytotoxic for dex-resistant primary MM cells with relative sparing of normal cells perhaps[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | BTdCPU | ||||||||||||
| CAS | 1257423-87-2 | ||||||||||||
| Formula | C13H8Cl2N4OS | ||||||||||||
| Molar Mass | 339.20 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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BTdCPU
CAS: 1257423-87-2 F: C13H8Cl2N4OS W: 339.20
BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apop
Data collection：peptidedb@qq.com
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