| Bioactivity | BTK-IN-8 is a potent selective peripheral covalent BTK inhibitor (IC50=0.22 nM; Kd=0.91 nM). BTK-IN-8 has good whole blood CD69 cellular potency (IC50=0.029 µM)[1]. |
| Target | IC50: 0.22 nM (BTK) |
| Invitro | BTK-IN-8 (compound 42) shows potent target occupancy in Ramos cells (IC50=3.1 nM) and inhibits BTK-dependent TMD8 cells proliferation (IC50= 1.6 nM)[1]. |
| Name | BTK-IN-8 |
| Formula | C26H36N6O3 |
| Molar Mass | 480.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ma B, et al. Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors. Bioorg Med Chem Lett. 2022, 60:128549. |